Epigenomes

Epigenetics, defined as the study of the information carried by the genome that is not encoded by DNA, as well as Epitranscriptomics, defined as the sum of the functionally relevant changes to the transcriptome that do not involve a direct change in the RNA sequence, are two of the most rapidly expanding fields, with clear therapeutic implications. The scope of Epigenomes includes, but is not limited to the following subjects: Functional studies dealing with identification/modus operandi/structure–function relationships or biological activity of methylases, demethylases, acetylases, methyl-binding proteins, or any other type of enzymes involved in DNA, RNA or histone modifications; Studies reporting genome-wide epigenetic status of cells or tissues in specific biologically relevant contexts; Studies describing insights into the role of epigenetics and epitranscriptomics in physical diseases (e.g., cancer, premature aging, allergy, obesity) and psychopathologies (e.g., schizophrenia, autism, addiction); Studies describing the effect of environmental changes on the epigenetic or epitranscriptomic status of cells or tissues; Studies describing the inheritance or fixation of epigenetic characteristics; Description of novel methods to study DNA methylation, histone methylation, RNA modifications, histone acetylation or other types of epigenetic and/or epitranscriptomic modifications in a global fashion; Studies describing novel tools and technologies for epigenetic or epitranscriptomic studies and therapeutics.